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The 2010 Major League All-Stars face one of the top clubs in Europe as they play Manchester United. The match will take place at Reliant Stadium in Houston, Texas on Wednesday, July 28, 2010. Kickoff is scheduled for 20:30 EST, 19:30 local time Houston, 17:30 on the West Coast, and 01:30 UK time (technically July 29).

It will be televised on ESPN2 & ESPN Deportes in the United States, Setanta Sports in Ireland, GolTV in Canada, Al Jazeera Sport in the Middle East. ESPN in the United Kingdom, and on Sky Sport 1 in Italy.